Senior Director, Precision Medicine Therapeutic Area Lead - Cardiometabolic/General Medicine

Career Category

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Director, Precision Medicine Therapeutic Area Lead – Cardio/Metabolic

What you will do

Let’s do this. Let’s change the world. In this vital role, you will act in conjunction with the General Medicine/Cardiometabolic Therapeutic Area Head to drive the development and execution of Precision Medicine objectives. As the Precision Medicine Therapeutic Area Lead, you will guide the strategic vision, execution, and integration of translational and precision medicine strategies across asset and above-asset programs throughout the product lifecycle.

You will:

• Lead cross-functional teams to develop and implement phase-appropriate, integrated biomarker and human data strategies to support translational pharmacology and inform patient stratification/selection.
• Develop, lead, and serve as the strategic integrator of diverse stakeholder input and multiple lines of scientific and clinical evidence to create precision medicine strategies at the asset and indication level.
• Shape the strategic vision to enhance the value of the portfolio through clinical biomarker target identification, indication selection, early demonstration of biological activity, and patient stratification—including reverse translational insights.
• Lead all aspects of precision medicine approaches by incorporating mechanistic insights and multi-omics data (e.g., genomic, proteomic) into actionable clinical development strategies.
• Serve as the primary translational bridge between Research and Development, advising on clinical proof-of-concept, target engagement, dose selection, and reverse translational strategies for assets in the clinic.
• Drive innovation to shape therapeutic area strategy, including disease endotyping, indication prioritization, and combination approaches, while also supporting regulatory and access evidence generation plans.
• Engage cross-functionally to evaluate, propose, and present strategies for data sourcing, collaborative partnerships, and funding needs to the appropriate Commercialization Governance Forums.
• Build and maintain strong external collaborations with academic institutions, industry partners, and key opinion leaders to accelerate precision medicine innovation in cardiometabolic diseases.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a strategic thinker and scientific leader with a passion for patient-centered drug development and precision medicine.

Basic Qualifications:

Doctorate degree and 5 years of relevant industry or academic translational research experience

Or

Master’s degree and 8 years of relevant experience

OR

Bachelor’s degree and 10 years of relevant experience

Preferred Qualifications:

• MD, PhD, or MD/PhD with 8+ years of pharmaceutical/biotech experience focused on clinical development and translational science in cardio/metabolic diseases
• Deep expertise in translational research, clinical biomarkers, and precision medicine approaches in cardiovascular, metabolic, or renal disease
• Scientific and analytical expertise in integrating multiple data sources e.g. –omic, clinical, Real world evidence (RWE) to inform precision medicine approaches
• Demonstrated ability to develop and implement successful biomarker strategies across early and late-stage clinical programs
• Experience working in matrixed, cross-functional teams and leading external partnerships
• Knowledge of clinical trial design, GCP, and regulatory pathways for biomarker and diagnostic development
• Exceptional communication skills and ability to influence internal collaborators and external partners
• Demonstrated success in mentoring and growing scientific teams

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team.

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Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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